Saturday, April 19, 2025

The Human Protein Atlas (Neuropeptide Version)


The extra you examine the mind, the extra unknowable it turns into. The extent of complexity is baffling, and that is true whether or not the mind belongs to a human or a crab.1 The most recent uptick in human mind complexity was revealed from evaluation of postmortem tissue in 17 subregions of prefrontal cortex (PFC). Zhong and colleagues (2022) discovered that 60 neuropeptides and 60 neuropeptide receptors are expressed in at the very least one of many PFC subregions.

 

All the information are freely obtainable (hyperlinks are within the open entry article) and included into the Human Protein Atlas which has about 15 million particular person net pages (in response to Wikipedia).

Footnote

1 Marder et al., 2022:

There’s a rising literature that means that circuits can have
degenerate options, that’s comparable wanting habits with totally different
underlying parameters throughout people. …  Furthermore, repeated
efficiency of the identical process is usually related to variable exercise
within the community producing this process [57∗∗].

 

Reference

Zhong, W., Barde, S., Mitsios, N., Adori, C., Oksvold, P., Feilitzen, Okay.
V., … & Hökfelt, T. (2022). The neuropeptide panorama of human prefrontal cortex. Proceedings of the Nationwide Academy of Sciences,
119(33), e2123146119. 

modified from Fig. 2 (Zhong et al., 2022). Expression ranges of (A) Neuropeptides (NP) and (B) Neuropeptide Receptors (NPR) in human PFC. The colour code signifies the kind of genes (orange, precursor; inexperienced, NP; blue, NPR). Crimson arrows in A and B level to the transcripts studied with ISH (in situ hybridization).

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